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We don't only create products, we also deliver guaranteed results.
Our victory is to provide our partners with concrete, innovative and safe results.
Our biomaterials are entirely made in an Italian production chain.

RE-BONE & SHELTER

A specific line of bone substitutes and cell separators designed to promote tissue regeneration
in bone and reconstructive surgery.

Osteoconductive capacity

Osteoconductivity refers to the situation in which the graft supports the attachment, survival and proliferation of osteogenic cells, providing an interconnected structure through which new cells can migrate and new vessels can form.

Sinus lift studies carried out in animal models have shown that the RE-BONEĀ® bone substitute can induce excellent (GBR) guided bone regeneration.

15 days after implantation of RE-BONEĀ® granules into a sheep's maxillary sinus, some vessels started to appear around the bone substitute, which is a fundamental requirement for the formation of new bone as it ensures:

  • nourishment and elimination of waste products
  • migration of osteoprogenitor cells into the graft
  • osteoprogenitor cell differentiation induced by the biomaterial
  • movement of differentiated osteoblasts for the deposition of new matrix

It can also be seen that osteoblasts approach the biomaterial/host tissue contact surface, and settle in the biomaterial structure with collagen fibre deposition (bright blue).

Confirming the results of in-vitro osteoinduction analysis, which demonstrated the expression of bone markers in undifferentiated cells after 21 days, even the histological analysis of bone grafts after 30 days showed a marked presence of osteoblasts penetrating into the pores of the biomaterial, where they started to deposit new collagen matrix. Osteoblast-deposited collagen contributes to the formation of the so-called WOVEN BONE, ie a very dense collagen structure, which will be mineralised at a later stage, thus becoming mature bone.

The excellent bone regeneration that can be seen from these images was made possible by the presence of numerous vessels in the vicinity of the biomaterial, which promote the migration of osteoprogenitor cells, as well as the supply of nutrients and the elimination of waste products.