Our products, tangible results.

We don't only create products, we also deliver guaranteed results.
Our victory is to provide our partners with concrete, innovative and safe results.
Our biomaterials are entirely made in an Italian production chain.

RE-BONE & SHELTER

A specific line of bone substitutes and cell separators designed to promote tissue regeneration
in bone and reconstructive surgery.

Osteoinductive capacity

Osteoinduction refers to the ability of the bone graft to induce undifferentiated stem cells (or osteoprogenitors) from surrounding tissues to differentiate into osteoblasts.

This property depends on the structure of the biomaterial: the more similar it is to the bone's extracellular matrix, the more osteoinductive is the biomaterial.

The RE-BONE® bone substitute preserves most of the bone cell matrix proteins which play a role in tissue regeneration.

By maintaining the extracellular structure, RE-BONE® stimulates tissue osteoinductivity. In vitro experiments with ADSCs demonstrate that the RE-BONE® bone substitute can induce an osteoblast-like phenotype in mesenchymal stem cells by stimulating specific bone markers such as osteopontin, osteonectin, osteocalcin and type I collagen. The overall expression of these proteins determines the bone phenotype.