RE-BONE®

RE-BONE® is the first bovine bone biomaterial treated at low temperature, manufactured through the innovative THERMAGEN process, which preserves the natural bone matrix and guarantees complete resorbability in physiological times (6-8 months).
Manufactured entirely in Italy, it complies with the strictest safety, sterility and quality standards.

WHY CHOOSE IT?
Its highly porous structure promotes optimal bone regeneration, making each procedure predictable and effective. It is the ideal choice for those seeking a superior clinical result and perfect compatibility with the patient’s bone tissue.

01 Compatibility and osteoconductivity

THERMAGEN heat shock treatment preserves the natural bone matrix and its porous structure; the decellularisation process, carried out at low temperatures, avoids ceramisation, resulting in effective vascularisation and cell colonisation at the site and complete resorption of the bone substitute.

02 Quality raw materials

The raw material of bovine origin is used in the production process and is carefully selected and subjected to strict controls according to current regulations. The choice of raw materials from cattle under 24 months of age, born and bred in Italy, and subjected to the strictest veterinary controls, guarantees a top-quality, safe and traceable end product.

03 Certified biocompatibility

The combination of the choice of raw material and the THERMAGEN low-temperature process results in a medical device with high biocompatibility, in compliance with ISO 10993-5:2009. Biocompatibility guarantees
a perfect interaction with human bone tissue, stimulating natural and safe regeneration.

04 Reduced healing time

RE-BONE® reduces the risk of complications and accelerates post-operative recovery. Compared to synthetic solutions, RE-BONE® stimulates the regenerative process due to its naturally porous structure similar to human bone, facilitating faster integration. This leads to improved comfort, greater efficiency for the dentist and a reduction in overall treatment time, increasing patient satisfaction.

01 Improved predictability of results

The consistency and purity make bovine bone substitute particularly suitable for treating bone defects of varying complexity, offering predictable and replicable results. Thanks to its optimal biological integration characteristics, RE-BONE® reduces the risk of early resorption or complications during the healing period, improving and long-term success probability for implants and
bone regeneration.

Range of Formats

The wide range of available formats allows for customised treatment, facilitating better adaptability to specific patient defects, and further improving further improving the accuracy of the result.

GRANULES IN VIALS

Typology:
spongy bone or
cortico-spongiosa

Grain sizes:
0.25-1mm; 1-2mm

Grammages:
0.25g; 0.5g; 1g; 2g; 5g

GRANULES IN VIALS

Typology:
cortical-spongiosa bone

Grain sizes:
0.25-1mm; 1-2mm

Grammages:
0.25g; 0.5g; 1g; 1.5g; 2g

BONE BLOCK

Typology:
spongy bone

Dimensions:
10x10x10mm; 10x10x20mm

Technology and Nature for True Regeneration

RE-BONE® is the result of an advanced process designed to preserve the structure and functional properties of natural bone tissue.

Thanks to the Thermagen protocol, we avoid the so-called “ceramization” of the bone substitute, ensuring a fully resorbable, highly biocompatible material with optimal macro- and microporosity to promote integration with the host tissue.

Every stage of the process is carefully designed, from the selection of raw materials sourced from healthy, traceable and environmentally responsible farming — to matrix decellularization, developed by a team of bioengineers and validated by recognized academic institutions.

The result is a bone substitute remarkably similar to human bone tissue, capable of promoting chemotaxis, stimulating osteoblast proliferation and supporting neoangiogenesis, thanks to the preservation of the extracellular matrix’s original three-dimensional structure.

Biocompatibility of the RE-BONE® Bone Substitute

Laboratory studies and scientific literature have demonstrated the regenerative efficacy of the RE-BONE® bone substitute manufactured by UBGEN®.

By culturing adipose-derived mesenchymal stem cells with the RE-BONE® bone substitute, an increase in cell proliferation was observed, reaching up to 35% more cells compared with the initial cell population after 14 days of culture.

Cell viability tests on osteoblasts cultured with the RE-BONE® bone substitute or with another commercially available bovine-derived biomaterial demonstrated higher cell survival: 90% for the comparison sample versus 96% for the RE-BONE® sample.