Ubgen Italy

SAFE-BONE®
HOW IS IT MADE?
SAFE-BONE® is produced through a selective laser melting process (SLM) using specific grade 5 titanium powders, historically recognized as inert and biocompatible. Each individual titanium mesh is designed to adapt to the patient's anatomical details, based on images created with CAD/CAM and an intra-oral scan provided by the clinician.

WHY USE TITANIUM MESH?

SAFE-BONE® is the most suitable solution in horizontal and vertical bone defects, in combination with a bone substitute.

While any early exposure of a non-resorbable membrane almost always leads to an infection capable of compromising the result of the surgical technique, indeed, several studies show that in case of exposure of the mesh the success of the regeneration is not affected and the regenerated bone volume is maintained.

SAFE-BONE® can be used alone or in combination with SHELTER® FAST or SHELTER® SLOW resorbable membranes.

Compared to pre-shaped titanium meshes, SAFE-BONE® offers many advantages, including speed and ease of application, requiring no further modelling or shaping adjustments.

UBGEN® offers the clinician the opportunity to fully customize the SAFE-BONE® structure, allowing for defining the thickness of the mesh, shape and size of the texture, as well as 3D planning of the placement of openings useful for future allocation of the implants.

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ACTI-BONE®
HYALURONIC ACID

Take advantage of the regenerative properties of high molecular weight hyaluronic acid, widely documented in oral surgery.

Hyaluronic acid is one of the main components of connective tissues together with collagen and elastin fibres. It is a polysaccharide naturally produced by the body in order to protect the tissues and keep them hydrated. It is possible to apply ACTI-BONE® directly on the surgical site, or use it in combination with RE-BONE® bone substitute to obtain the so-called "sticky bone" or with SHELTER® FAST or SHELTER® SLOW pericardium membranes to enhance their chemotactic capacity.

ACTI-BONE®, why use it in oral surgery?

Hyaluronic acid is characterized by the ability to retain a very high amount of water.

Anti-inflammatory properties Numerous studies report that hyaluronic acid is effective in minimizing the inflammation in the surgical site, thus facilitating bone regeneration.

Osteogenic and immunomodulatory properties In case of trauma at a local level, hyaluronic acid is naturally produced by the body in order to promote the regeneration of soft tissues.

Angiogenic properties The ability of hyaluronic acid to interact with specific membrane receptors makes it a stimulating factor for the migration and proliferation of endothelial cells.

Fibroblast proliferation High molecular weight hyaluronic acid is recognized for its chemotactic and stimulatory properties toward fibroblasts, involved in the synthesis of new collagen.

Bacteriostatic effect Scientific studies have shown that the clinical application of hyaluronic acid in surgical therapy reduces bacterial contamination of the surgery site and the risk of post-operative infections.

ACTI-BONE®finds its specific application in implant, periodontal, and extraction surgery, and in the treatment of peri-implantitis as a powerful adjuvant capable of regenerating bone tissue and protecting the implant and the implant site.

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UBGEN®
A CONSCIOUS CHOICE
THAT YOU CAN DO WITH YOUR EYES CLOSED.

WHY IS IT IMPORTANT TO HAVE A BEAUTIFUL SMILE?

There are two good reasons to take care of your teeth and want to smile again:

• A functional reason related to the correct chewing and consequent digestion and absorption of nutrients contained in food, posture and body health;

• 2. A psychological reason, as having healthy teeth improves aesthetics, increases well-being and self-esteem.

WHAT CAUSES BONE LOSS AND WHEN IS RECONSTRUCTION NEEDED?

  • Bone loss can be caused by several factors. A typical example is gum inflammation due to bacterial plaque which, if not removed with proper oral hygiene, affects the bone.

    In other cases, following a tooth extraction, bone thickness could be reduced. Even the use of removable dental prostheses that does not adequately stress the bone tissue, produces its resorption.

  • Other causes of bone loss can be due to trauma or pathologies such as peri-implantitis, with consequences such as: Loss of tooth or implant, Defects in chewing, Inability to insert the dental implant, Instability of the implant, Alteration of phonetics, Decreased self-esteem.
  • Regardless of the causes of bone loss, what matters is to proceed to a timely restoration of bone volume, to ensure a fast functional recovery of chewing and ensure the long-term stability of teeth and implants, as well as improve the aesthetics of teeth and gums. Human bone can regenerate, but in some conditions, such as when a large amount of bone tissue is missing, our body needs help.

What are biomaterials and what are they used for?

  • Biomaterials are inert bone grafts, used for repairing and regenerating bone tissue in the sinus or jaw. They are used in various fields of medicine, but mainly in orthopedic and dentistry. There are two main macro-categories into which biomaterials can be divided: bone substitutes and emembranes capable of protecting the bone graft in the area of intervention.

    Bone grafts, according to their origin, are divided into:

    AUTOLOGOUS Bone material taken from the patient themselves, from the sinus and jaw or from areas outside the oral cavity;

    HOMOLOGOUS Provided by regional and national musculoskeletal tissue banks, identified and authorized by the Ministry of Health;

    HETEROLOGOUS Of animal origin (bovine, equine, porcine) either synthetic, or chemical (called synthetic or non-absorbable.

  • In case of bone deficiency it is advisable to use RE-BONE® bovine graft. RE-BONE® is positioned in the area to be restored allowing the positive outcome of the intervention. In addition, RE-BONE® is resorbable, i.e. it retreats over time, letting the patient's body progressively rebuild its internal tissue.

Can animal biomaterials transmit infections or diseases to humans?

Sometimes the risk is present. However, RE-BONE®, the resorbable biomaterial of bovine origin UBGEN®, increases the level of safety to almost 100% because:

• The animals used are less than 24 months old to rule out the presence of bovine spongiform encephalopathy (mad cow disease).

• It is the only cattle treated at low temperature (thanks to the Thermagen process) that allows to make it almost completely resorbable.

• Il paziente, dopo poco tempo, svilupperà osso proprio e non avrà materiale residuo animale all’interno del proprio corpo;

• The patient, after a short time, will develop their own bone and will have no animal residue material inside their body.

• It comes from a 100% Italian supply chain and is subject to strict process control.

• It has CE certifications from the Italian National Institute of Health.

• It is also registered and certified in non-EU countries.

WHY ARE BIOMATERIALS USED?

Despite the characteristic hardness and strength, bone is not a static tissue, but is constantly changing and repaired. This process is called bone remodeling. Every year about 10% of our overall bone mass is renewed. The bone substitute (biomaterial), keeping the bone volume unchanged and ensuring the stability of the implant screws, promotes the process of regeneration and healing of the surgical wound.

How does bone reconstruction contribute to implant stabilization?

Following the tooth extraction, near the extractive alveolus, both bone and gum tend to a progressive and natural reduction of their volume. In order to guarantee stability to the implants, it is good to fill the extraction cavities with a biomaterial that will help to maintain the bone volume.

WHAT ARE THE INDICATIONS TO FOLLOW AFTER SURGERY?

It is necessary to adopt appropriate post-operative behaviors to reduce recovery times and minimize the onset of any complications. On the opposite page we list the five main post-operative indications to be adopted after bone regeneration surgery. In case of pain or any doubt, always consult your dentist.

• Treat any swelling with cold compresses.

• In case of pain, ask your dentist, if you have not already done so, for an adequate pain reliever.

• For the first few weeks, during daily oral hygiene procedures, avoid the operated area, use an antibacterial mouthwash and, later, in the area surrounding the wound use only a toothbrush with soft bristles.

• Avoid coffee, alcohol and cigarettes for 2-3 days after surgery.

This warning reduces the risk of post-operative bleeding and improves wound healing (smoking and insufficient oral hygiene can have a significant negative impact on the outcome of therapy).

• Even if the recovery proceeds smoothly, respect the schedule of check-ups set by your dentist.

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UBGEN
EXPO, MEETING
& CONGRESSES

VISIBILITY, CREDIBILITY AND CONNECTION
Trade fairs, conferences and events always have represented a fundamental moment of comparison and exchange between the companies, potential customers and partners, a privileged showcase to put in highlight the differentiating and competitive characteristics of products and services. UBGEN has always valued the direct relationship with partners and the public, believing that the precious value of the relationship should be cultivated with constancy and presence. We are happy to meet again for the next must-sees international appointments and events that we organize for the purpose to encourage the meeting between the protagonists of the successful story that we are writing: different in terms of skills, united in the goal.

EXPO

THE POWER OF THE ENCOUNTER
We participate and are pleased to welcome you to the main globally recognized trade fairs of the sector because we believe in the business where it ispossible to establish direct contact, face to face with the interlocutors, develop authentic and deep relationships.

MEETING

THE IMPORTANCE OF UPDATING
The meetings focus on various topics in the periodontal and peri-implant fields,dealing with the constant evolution of techniques and approaches and modern rends adopted in the light of the new guidelines introduced by European Federation of Periodontology.

CONGRESSES

THE VALUE OF THE EXCHANGE
We organize and are Sponsors of scientific meetings and conferences that represent the ideal opportunity for comparison and the exchange of valuable knowledge, information and experience between dental professionals.

Book your meeting with us!

EAO

Monaco, 18-20 September 2025
EAO 2025 is one of the most anticipated scientific events in the field of implantology and bone regeneration, bringing together innovation, research, and international clinical practice.

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EXPODENTAL

Rimini, 15-17 May 2025
Expodental Meeting is one of the most important dental events in Italy, a key gathering for technological innovation, professional development, and networking among companies and industry professionals. This year, we will be present at the Ziacom ITS booth to showcase our regenerative solutions and engage with clinicians on integrated and predictable treatment approaches. Visit us at Pavilion C3 – Booth 111.

IDS

Cologne, 25-29 March 2025
Held biennially in Cologne, the International Dental Show is the largest event dedicated to the dental sector, attracting companies, professionals, and experts from around the world. It provides the perfect platform to explore the latest trends, showcase innovative solutions, and forge strategic collaborations.

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EAO

Milan, 24-26 October 2024
As one of the leading associations in the field of implant dentistry worldwide, the EAO is dedicated to improving patient care by bridging the gap between science and clinical practice. This year's congress will feature a joint event with the IAO and SIdP, fostering collaboration and innovation in the field. UBGEN will participate in the scientific program, leading a hands-on session conducted by Prof. Meloni.

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DENTAL WORLD – INTERNATIONAL DENTAL EXHIBITION AND CONGRESS

Budapest - Hungary, 10-11-12 October 2024
The international dental trade fair is the ideal place for manufacturers to boost their sales, establish new connections, showcase their products, meet distributors and future partners, as well as engage personally with regional professionals.

DLS9 – INTERNATIONAL DENTAL CONFERENCE & EXHIBITION

Bahrain, 3-4 October 2024
At the DLS9 Bahrain International Dental Conference & Exhibition, we will witness advancements in knowledge and innovation within the field of dentistry. The exhibition, organized alongside the conference, aims to actively engage companies in the medical and pharmaceutical sectors. It is designed to facilitate communication and strengthen ties between sponsors, exhibitors, and healthcare professionals, with the goal of enhancing interactions among industry professionals both locally and globally.

6° International Congress FNOMECEO

Bari, 12-14 September 2024
The 6th International Congress on "Technological Innovations and Experimental Protocols in Periodontology, Oral Surgery, and Orthodontics" will be held at the Aldo Moro University of Bari. This free event, accredited for ECM credits, is sponsored by the FNOMCeO and targeted at surgeons, dentists, nurses, and dental hygienists. It offers a vital opportunity to stay updated on the latest technological innovations and the most advanced experimental methods.

EXPODENTAL MEETING RIMINI

Rimini, 14-15-16 May 2024
Expodental Meeting, the most important Italian dental event. It skilfully mixes recreational and convivial moments with the presentation of innovations, practical demonstrations and scientific events.

IAO NAPOLI

Naples, 11-12-13 April 2024
IAO Napoli is a three-day meeting focused on "The Patient at the Core of Therapy: Implant-Prosthetic Treatment and Complication Management." Attendees will explore topics including Peri-implantitis, Treating Edentulous Patients, and Complication Treatment.

EXPODENTAL MADRID 2024

Madrid, 14-15-16 March 2024
Expodental is the reference fair for the dental sector at an international level and the undisputed leader on the national scene. It aims to show all dental professionals the latest technologies and trends in a comfortable, accessible and innovative environment for both exhibitors and visitors.

AEEDC DUBAI 2024

Dubai, 6-7-8 February 2024
AEEDC Dubai is "the world's largest annual scientific dentistry conference and exhibition". AEEDC Dubai has been recognized as a beacon of knowledge and a point of reference for dental experts, academics and dental professionals from across the region and all corners of the globe.

ADF PARIGI 2023

Paris, 28 November - 2 December 2023
The ADF Congress is the leading event in the field of dentistry and continuing education in Europe. An international fair with 12,700 m2. of exhibition spaces on 4 levels. The ADF Congress is the leading event in the field of dentistry and continuing education in Europe.

UBGEN® GBR

Genoa, 3 September 2023
Resorbable “Dome” Device in GBR. The goals of the course, led by Dr. Stefano Parma Benfenati, are to learn the surgical techniques and describe an approach step by step for regenerative procedures illustrated in a didactic and detailed way, after video tutorial projection and immediate execution by the participant. Moreover, the course provides the ECM accreditation.

XXIII DENTAL WORLD

Budapest, 13-14-15 October 2023
The presence of more than 300 dental manufacturers will ensure first-hand experience of all the innovations that will be seen in dental offices for years to come. Furthermore, live talks, demonstrations, workshops and hands-on training sessions will provide visitors with knowledge that can be applied immediately, while the social event will help participants get to know not only Budapest but also each other better.

IAO Milan 2023

Milan, 5-6-7 October 2023
This high-level event will feature world-class speakers and attract more than five thousand delegates from around the world for three days. The meeting will provide great opportunities for networking and sharing the latest news and research on innovative technologies and treatment strategies.

EAO Berlino

Berlin, 28-29-30 September 2023
This high-level event will feature world-class speakers and attract more than five thousand delegates from around the world for three days. The meeting will provide great opportunities for networking and sharing the latest news and research on innovative technologies and treatment strategies.

1° National Dentist Education Congress

Padua, 21-22-23 September 2023
First national congress entitled: "Technological innovation, aesthetics and new challenges for implantological and regenerative surgery", in the wonderful setting of the San Gaetano Cultural Center where UBGEN will participate as Sponsor.

5th International Congress

Bari, 14-15-16 September 2023
It's a training meeting of sure interest not only for dentist colleagues, but also for surgeons, postgraduates, masters students and dental hygienists, who will be able to keep up to date on specific issues of periodontology, deepening the technological innovations and experimental protocols, oral surgery and orthodontics.

III ZYGOMA DAY

Florence, 14-15 July 2023
The surgeon who is preparing for techniques of this caliber must have very great skills in the management of severe jaw atrophies without forgetting that zygomatic and pterygoid implantology is a very valid way to go only when there are the right indications". During the congress there will also be a poster session, where participants will be able to exhibit their scientific work.

1°International Congress SISS

Turin, 15-16-17 June 2023
The Socket-Shield is now a consolidated technique, which allows us to make the most of the "time zero", that is the moment of extraction, because it allows us to insert the implant, and often also a temporary one, and to keep all the hard and soft tissues present at zero time. With a truly minimally invasive surgical procedure. However, there are specific indications, as well as other approaches.

UBGEN® WORKSHOP

Clinica Ezio Costa - Sona (VR), 12 June 2023
Absorbable "Dome" device in GBR. Under the supervision of the tutor Prof. Stefano Parma Benfenati, the objectives of the workshop will be: to learn the surgical techniques, to describe a "step by step" approach for the regenerative procedures illustrated in a didactic and detailed way, after the video tutorial screening and immediate execution by of the participant, transmit to the clinician the ability to interpret the anatomical characteristics of soft, hard tissues and bone defects.

NEW CONSERVATIVE APPROACH IN THE RESOLUTION OF COMPLEX CASES

Forte di Bard - Bard (AO), 10 June 2023
Through the new tools for root canal treatment, with the help of regeneration and minimally invasive surgery, thanks to the adhesion, following an additive approach, it is possible to solve complex cases significantly reducing the biological and economic cost of the patient.

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Prof. Ugo Covani

Camaiore (LU), Italy
Sinus lift.
Maxillary sinus lift procedure with lateral approach
Placement of RE-BONE mixed with PRF
Open window on the lateral breast wall
Use of the SHELTER membrane to protect the Schneider membrane
Preparation of RE-BONE mixed with PRF
Closure of the site; removal of sutures after two weeks

Dr. Filippo De Paolis
Dr. Michele Benegiamo
Dr. Viviana Prete

Techniques and materials in implant-supported rehabilitation, maxillary sinus lift and contextual GBR.
Vertical and horizontal maxillary bone defects
RE-BONE biomaterial in situ and resorbable SHELTER pericardium membrane
Sinus lift and lateral osteotomy
SHELTER resorbable pericardium membrane covering the graft and retention pins
Sinus lift with lateral and contextual GBR osteotomy
Closure of the site; removal of sutures after two weeks

Dr. Walter Stablum

Borgo Valsugana (TN), Italy
Regenerative therapy of an intraosseous defect with a minimally invasive approach.
Initial clinical survey
Defect filled with RE-BONE biomaterial and amelogenins
Incision and unglued flap
Sutures and cyanoacrylate
8mm intraoperative probe and enamel beads
Clinical and radiographic situation at 6 months

Dr. Stefano Parma Benfenati

Ferrara, Italy
Anterior Tooth Replacement with two-stage implant and regenerative approach technique.
X-ray of the defect. Full-thickness flap elevation
RE-BONE Biomaterial positioned to fill the defect
Defect diagnosis and implant placement
Positioning of SHELTER resorbable pericardium membrane to cover the graft, and site closure with PTFE sutures. Clinical image after a 9 month- uneventful healing
Resorbable "dome" and evaluation of correct implant placement
Comparative clinical images, at II stage implant surgery

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We certify that the entire range of medical devices described above is CE marked and manufactured in accordance with the requirements of Directive 93/42 / EEC implemented in Italy with the DLGS. n. 46 dated 24-02-97 and subsequent amendments. The company operates in compliance with UNI EN ISO 9001 standards.
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