RE-BONE®
WHY CHOOSE IT?

Because it works.

  • UBGEN® is the only certified Italian company that processes bovine material at low temperatures. Most of the commercially available biomaterials do not use raw material of bovine origin, or exploit bovine bone treated at high temperatures.

    This means that the resorption index is significantly lower and that the bone graft remains in the oral cavity even after many years.

    At UBGEN® we exploit the winning characteristics of the bone substitute of bovine origin, treated at low temperature through our unique Thermagen production process. The bone substitute thus produced has been shown to facilitate in situ volumetric stability, thanks to the superficial cracking of the granules technology. Moreover, this low temperature cleaning process prevents ceramization, while keeping the bovine bone matrix perfectly resorbable and biocompatible.

    RE-BONE® is completely reabsorbed in 6-8 months. Its safety is ensured by the choice of raw material in compliance with the standards required in the reference protocol.

The first bone graft of bovine origin processed at low temperature

  • ▷ Fully resorbable

    ▷ Processed at low temperatures thanks to the Thermagen production process

    ▷ Produced by an entirely Italian supply chain

    ▷ MCE marked as a product compliant with Directive 93/42 EEC (CE 0373)

The bone substitute of bovine origin treated at low temperature through the innovative Thermagen production process, produced by an entirely Italian supply chain.

  • Compared to the presence on the market of bone substitutes of bovine origin treated at high temperatures or produced with raw materials from other sources (porcine, equine, synthetic), at UBGEN® we enhance the winning characteristics of the bovine bone substitute with the Thermagen innovative production process at low temperatures. Thanks to this protocol, we are able to avoid the so-called "ceramization" of the bone substitute, thus ensuring its total resorption and giving it high biocompatibility as well as adequate macro/microporosity.

    The decellularization process of the Thermagen raw material was developed by a team of internal and external bioengineering experts and subsequently proven by tests performed by authoritative University Departments.

    Together with the Thermagen production process, it is the choice of the raw material that makes the difference. At UBGEN® we are aware of the details of each step of the production chain: from the wholesomeness of the land used for grazing, to the natural cultivation used for the production of forage, to the healthful state of the facilities that welcome the animals themselves.

    If animals live and grow well, in a healthy environment, that is respected in its territorial characteristics, the derived products intrinsically meet the health and safety requirements.

    RE-BONE® is a bone substitute that is very similar to human bone tissue. Therefore, it is able to create an environment favourable to chemotaxis, osteoblast proliferation and neoangiogenesis thanks to the maintenance of the native three-dimensional structure of the extracellular matrix.

Biocompatibility of RE-BONE® bone substitute

Laboratory studies and scientific literature have demonstrated the regenerative efficacy of RE-BONE® bone substitute produced by UBGEN®.

By cultivating adipose-derived mesenchymal stem cells with RE-BONE® bone substitute, an increase in cell proliferation was documented, until reaching 35% more cells than the starting cell population after a 14-day cell culture.

Cell viability tests of osteoblasts cultured with RE-BONE® bone substitute or with other commercially available bovine-derived biomaterials have shown increased cell survival: 90% (comparison sample) versus 96% (RE-BONE® sample).

Microporosity of the mineral structure

  • In literature it is widely documented that the microporosity of biomaterials is an important factor for tissue regeneration. By increasing the contact surface of the graft with the cells of the surrounding tissue, the possibility for the biomaterials to be colonized by bone progenitor cells is increased.

    Nanostructured biomaterials, in fact, mimic the extracellular matrix of the natural bone, creating a micro-environment that promotes cell adhesion, proliferation and differentiation.

    Scanning electron microscope (SEM) analyses were therefore conducted to qualitatively evaluate the microporosity of the RE-BONE® bone substitute.

    The SEM analyses to qualitatively evaluate the microporosity of the RE-BONE® bone substitute demonstrate how the micro-roughness of the material, in terms of opening, cracking and non-continuity of the surface, is also present at a microscopic level (compatible with the cellular dimensions of the osteoblasts). The presence of cracks inside the granule is also evident, which will allow the cells and blood vessels to colonize the graft in depth, shortening the resorption time of the bone substitute itself.

CLINICALAPPLICATIONS

Maintenance of alveolus and bone crest.

Maxillary sinus lift surgery.

Horizontal augmentation in 2-wall defects.

Vertical augmentation in 2-wall defects.

Dehiscences and fenestrations in peri-implant lesions.

Periodontal regeneration in intra-osseous defects and 2-3 wall furcation defects.

  • RE-BONE® Cortico-cancellous granules
    Typology weight Range between Range to Code
    Cortico-cancellous granules 0,25g 0,25 mm 1 mm BM01A (pack of 1) BM01A6 (pack of 6)
    Cortico-cancellous granules 0,5g 0,25 mm 1 mm BM01A (pack of 1) BM01A6 (pack of 6)
    Cortico-cancellous granules 0,5g 0,25 mm 1 mm BM01B (pack of 1) BM01B6 (pack of 6)
    Cortico-cancellous granules 1g 0,25 1 mm BM01C (pack of 1) BM01C6 (pack of 6)
    Cortico-cancellous granules 2g 0,25 mm 1 mm BM01D (pack of 1) BM01D6 (pack of 6)
    Cortico-cancellous granules 0,5g 1 mm 2 mm BM01E (pack of 1) BM01E6 (pack of 6)
    Cortico-cancellous granules 1g 1 mm 2 mm BM01F (pack of 1) BM01F6 (pack of 6)
    Cortico-cancellous granules 2g 1 mm 2 mm BM01G (pack of 1) BM01G6 (pack of 6)
    Cortico-cancellous granules 5g 1 mm 2 mm BM01H (pack of 1) BM01H6 (pack of 6)
  • RE-BONE® Cancellous granules
    Typology weight Range between Range to Code
    Cancellous granules 0,25g 0,25 mm 1 mm BM01I (pack of 1) BM01A6 (pack of 6)
    Cancellous granules 0,5g 0,25 mm 1 mm BM01A (pack of 1) BM01I6 (pack of 6)
    Cortico-cancellous granules 0,5g 0,25 mm 1 mm BM01J (pack of 1) BM01J6 (pack of 6)
    Cancellous granules 1g 0,25 1 mm BM01K (pack of 1) BM01K6 (pack of 6)
    Cancellous granules 2g 0,25 mm 1 mm BM01L (pack of 1) BM01L6 (pack of 6)
    Cancellous granules 0,5g 1 mm 2 mm BM01M (pack of 1) BM01M6 (pack of 6)
    Cancellous granules 1g 1 mm 2 mm BM01N (pack of 1) BM01N6 (pack of 6)
    Cancellous granules 2g 1 mm 2 mm BM01O (pack of 1) BM01O6 (pack of 6)
    Cancellous granules 5g 1 mm 2 mm BM01P (pack of 1) BM01P6 (pack of 6)
We certify that the entire range of medical devices described above is CE marked and manufactured in accordance with the requirements of Directive 93/42 / EEC implemented in Italy with the DLGS. n. 46 dated 24-02-97 and subsequent amendments. The company operates in compliance with UNI EN ISO 9001 standards.

UBGEN Srl Viale del Lavoro 14, 35010, Vigonza (PD), Italy - Phone: +39 049 628 630

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