UBGEN® is the only certified Italian company that processes bovine material at low temperatures. Most of the commercially available biomaterials do not use raw material of bovine origin, or exploit bovine bone treated at high temperatures.

This means that the resorption index is significantly lower and that the bone graft remains in the oral cavity even after many years.

At UBGEN® we exploit the winning characteristics of the bone substitute of bovine origin, treated at low temperature through our unique Thermagen production process. The bone substitute thus produced has been shown to facilitate in situ volumetric stability, thanks to the superficial cracking of the granules technology. Moreover, this low temperature cleaning process prevents ceramization, while keeping the bovine bone matrix perfectly resorbable and biocompatible.

RE-BONE® is completely reabsorbed in 6-8 months. Its safety is ensured by the choice of raw material in compliance with the standards required in the reference protocol.

Compared to the presence on the market of bone substitutes of bovine origin treated at high temperatures or produced with raw materials from other sources (porcine, equine, synthetic), at UBGEN® we enhance the winning characteristics of the bovine bone substitute with the Thermagen innovative production process at low temperatures. Thanks to this protocol, we are able to avoid the so-called "ceramization" of the bone substitute, thus ensuring its total resorption and giving it high biocompatibility as well as adequate macro/microporosity.

The decellularization process of the Thermagen raw material was developed by a team of internal and external bioengineering experts and subsequently proven by tests performed by authoritative University Departments.

Together with the Thermagen production process, it is the choice of the raw material that makes the difference. At UBGEN® we are aware of the details of each step of the production chain: from the wholesomeness of the land used for grazing, to the natural cultivation used for the production of forage, to the healthful state of the facilities that welcome the animals themselves.

If animals live and grow well, in a healthy environment, that is respected in its territorial characteristics, the derived products intrinsically meet the health and safety requirements.

RE-BONE® is a bone substitute that is very similar to human bone tissue. Therefore, it is able to create an environment favourable to chemotaxis, osteoblast proliferation and neoangiogenesis thanks to the maintenance of the native three-dimensional structure of the extracellular matrix.