GF-ONE PLUS® is the first integrated system CLASS II A CERTIFIED for the preparation of platelet concentrates specifically designed for bone surgery in dentistry.

Usually, in the blood separator market only the equipment for preparing platelet concentrates is provided, and these devices are normally designed for general use.

At UBGEN we have created instead a specific system to be used in dental surgery supported by technical training, start-up assistance and authorization of the dental practice.

This technology and its applications, which provide a unique and complete solution, allow the clinician to achieve exclusive benefits in terms of predictability of results.

The role of platelets

Platelets play a key role in controlling the first phase of haemostasis. In recent years, the identification of some special molecules inside them - known as Platelet Growth Factors - has revealed new perspectives and possible applications in the medical and surgical field.

Numerous biochemical studies have shown a growth-stimulatory effect on different cell lines, with platelets acting as metabolic inducers: they release growth factors that immediately come into action, stimulating the regeneration of damaged tissues, and significantly accelerating the healing process.

Each of these identified factors targets a specific cell line (skin, muscle, ligaments and tendons, bone, blood vessels), acting on the metabolism of the treated tissue with a synergistic, anti-inflammatory and reparative action.

Growth factors main functions

Growth factors are locally and constantly released through continuous platelet degranulation.

Growth factors main properties are listed below:

  • They proactively act towards angiogenic processes;
  • They are chemotactic towards biological steps and mitogenic towards the cells they encounter, activating a multiplier effect;
  • They significantly increase cell membrane receptor expression.

The APG technique

The APG® (Autologous Platelets Gel) technique is the most advanced autologous system for obtaining a Platelets Concentrate both in liquid and gel.

It is based on the activation of the patient’s own platelets, which are concentrated through centrifugation of a small sample of autologous blood (7-10 ml) and used to stimulate and accelerate tissue regeneration.

This methodology offers extraordinary results against many diseases, without side effects. Moreover, it reduces the recovery time after surgery.

Patient benefits

Applying APG® to the area to be treated allows a faster and of better-quality healing process.

Technically, it is an autograft as the patient’s own platelets are reused on the same patient to generate and accelerate the reparative processes and tissue regeneration.

Benefits include:
  1. Reduced risk of infection and pain relief;
  2. Improved healing time and quality of hard & soft tissue, thus accelerating osteogenetic processes;
  3. Possibility of combining it with medicaments and/or other biomaterials such as grafts, and implants.

APG applications


Several studies suggest that the use of a platelet concentrate, either alone or combined with other surgical techniques, or even as a support to implant devices, improves the final success of operations, significantly increasing patient’s comfort by reducing healing time.

In dentistry, the APG® method is used for:

  • Accelerating the healing of surgical wounds;
  • Reducing inflammation and post-operative discomfort;
  • The surgical treatment of post-extraction alveolus associated with biomaterials;
  • Maxillary sinus surgery;
  • Periodontal and muco-gingival surgery;
  • The surgical treatment of patients with bisphosphonates-induced osteonecrosis.

In all these treatments, the adhesive nature of APG® facilitates the handling of implant material, improving hemostasis and wound closure compared to the traditional technique.

Furthermore, recent studies have shown that the use of platelet-rich plasma increases microvascular proliferation in the early stages of healing, followed by a better osteoblastic activity.


APG® concentrate in cosmetic surgery In the dermis, exposure to UVB rays stimulates collagenase production by fibroblasts present in the skin that degrade collagen. This process causes the alteration of the disposition of the elastic tissue reducing the structural integrity of the dermis, the first cause of wrinkles and loss of skin elasticity.

Since APG® concentrate contains a number of growth factors that regulate skin regeneration, it can induce the synthesis of collagen and other components of the skin by stimulating and activating fibroblasts, thereby encouraging cells to rejuvenate.

It has been shown that the use of APG® concentrate during cosmetic laser treatments increased skin elasticity, the amount of collagen and the number of fibroblasts, demonstrating a better cosmetic result and faster wound healing.

The APG® method is used for:
  • Treating forehead wrinkles, wrinkles around the eyes, nasolabial wrinkles, wrinkles on the neck and on the neckline;
  • Treating acne scars;
  • Toning the skin and reducing sagging skin;
  • Treating stretch marks;
  • Treating and re-epithelialising skin wounds and ulcers.


In recent years, clinical experience has shown that acute traumatic injuries of the muscles, tendons, and joint capsules significantly benefit from treatment with platelet growth factors, also in relation to the age of patients, the affected area of the body and its degree of functionality.

Young patients and athletes benefit from the use of platelet growth factors by reducing the time of functional damage, guaranteeing a faster recovery.

More specifically, the application of APG® concentrate has proved particularly effective in the treatment of acute and chronic injuries of tendons, osteoarthritis, and epicondylitis.


It was recently found that treatments with platelet concentrate on patients affected by alopecia areata or baldness result in increased hair growth and thickness, as well as an increased number of hair follicles and improved microcapillary angiogenesis.

This treatment has no side effects; it is well tolerated and offers tangible results from the very first use and in a short time, both in terms of reduced hair loss and improved re-growth and thickening of the hair.
We certify that the entire range of medical devices described above is CE marked and manufactured in accordance with the requirements of Directive 93/42 / EEC implemented in Italy with the DLGS. n. 46 dated 24-02-97 and subsequent amendments. The company operates in compliance with UNI EN ISO 9001 standards.

UBGEN Srl Viale del Lavoro 14, 35010, Vigonza (PD), Italy - Phone: +39 049 628 630

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