Collagen plays a chemotactic action on the cell line of monocytes/macrophages, from which osteoclasts derive. These cells in turn stimulate angiogenesis, thanks to the secretion of angiogenic growth factors. Collagen is also able to activate the receptors on the cellular membrane of the platelets, thus facilitating haemostasis.
Collagen stimulates a chemoattractant action on the precursors of osteoclasts, cells that through their action reabsorb the mineral component and collaborate with the osteoblasts in the rearrangement and remodelling of the bone in which the implant is placed.
Collagen, by binding itself to fibronectin, promotes the anchoring of mesenchymal stem progenitor cells on which it exercises its chemotactic activity and induces the osteoblastic differentiation.
Collagen is able both to increase osteoblast proliferation speed and to guide the connective tissue regeneration.
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