• stimulate platelet activity
• predispose the surface of the implants to be rapidly colonized by the bone
• increase the bone/implant contact area
• shorten recovery times
For our users, this means being able to make a safe choice, with predictable results even in patients defined as high-risk.
In the regenerative processes, in fact, the osteoblastic cells initially deposit a collagen matrix which is then mineralized. This collagen matrix exerts a series of positive biological effects. This in fact promotes the adhesion of osteoblasts and osteoclasts and acts as a cofactor for numerous growth factors.
The use of collagen was a decisive choice for UBGEN® in order to create a biological solution that anticipates future needs in the world of dentistry.
Test on the production of the enzyme alkaline phosphatase (ALP) by osteoblasts cultured on titanium bars and titanium bars coated with collagen. The results after 3 and 7 days of culture show that the collagen-coated titanium produced more ALP, the main marker of osteoblastic activity, confirming the role of collagen inducing pro-osteogenic activity.
The collagen coating was applied to titanium screws which were then inserted into rabbit femurs for an in vivo assessment after four weeks. The trabecular bone showed improvements of the bone-implant contact surface compared to the control (non-treated titanium implant) which corresponds to faster regeneration of the bone surrounding the implant site.
A second set of implants was inserted into rabbit femurs and histomorphometric analyses were performed at two and four weeks (Fig. 12). After two weeks, these analyses showed a significant increase in bone-implant contact surface, whereas at four weeks bone healing was complete on both implant surfaces.
These data support the hypothesis that collagen induces faster bone production at the interface with the implant in accordance with the biological role of collagen.
• placement in native bone D4p> • uncovering after 10 weeks
• ASA 1 patient
Upon uncovering, two tests were performed to demonstrate the achievement of implant stability: the percussion test and the torque removal test at 20 N∙cm. All surgical steps were documented with x-rays and photographs. After one year, all the implants are correctly osseointegrated and stable, as verified when the implant was uncovered after ten weeks.
The results, therefore, demonstrate that ACTIGEN® surface treatment allows for an increase of up to 3 times the BIC (Bone Interface Contact) compared to the traditional surface in just two weeks.